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https://www.selleckchem.com/pharmacological_epigenetics.html Endoscopic sutures can be used in various clinical situations where closure or fixation is needed. Stents that migrate and dislocated probes can be fixated by endoscopic sutures. The sutures can be used to stop gastrointestinal bleeding. It is possible to close perforations, leaks and fistulas with endoscopic sutures, but as with ordinary sutures, the indication must be correct for the procedure to be successful. Endoscopic sleeve gastroplasty (ESG) can be done by a series of sutures reducing the volume of the stomach. Defects after endoscopic resections, where bleeding or perforations can be expected, can be closed with endoscopic sutures. Complications are uncommon but intraabdominal fluid collection may occur after ESG. Endoscopic sutures have the same possibilities and limitations as traditional or laparoscopic sutures. Properly used, the method is safe, but the instruments are still difficult to work with and require an experienced endoscopist who has undergone proper training.Obesity is a growing health problem and challenge to the health care systems in the western world. Available treatment is limited to lifestyle modifications, cognitive therapy, drugs and bariatric surgery. On one hand, lifestyle changes and pharmacological treatment have very limited long-term effects on obesity. On the other hand, bariatric surgery is effective to maintain long-term weigh reduction but is associated with complications and reaches less than 2 % of patients with indication for surgery. Thus, there is a gap in the management of patients with obesity, and endoscopic bariatric therapies might fill that gap by providing effective, repeatable and reversible alternatives for selected patients with obesity. This article introduces endoscopic methods to achieve weight loss with special focus on endoscopic sleeve gastroplasty (ESG). Data in the literature demonstrates that ESG is effective in reducing total and excessive

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