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https://www.selleckchem.com/products/DAPT-GSI-IX.html High-dose-rate (HDR) brachytherapy is an alternative treatment to electron external beam radiation therapy (EBRT) of superficial skin lesions. The purpose of this study was to establish the selection criteria for HDR brachytherapy technique (HDR-BT) and EBRT in cutaneous oncology for various clinical scenarios. The study consists of two parts a) EBRT and HDR-BT treatment plans comparison analyzing clinical target volumes (CTVs) with different geometries, field sizes, and topologies, and b) development of a prediction model capable of characterization of dose distributions in HDR surface brachytherapy for various geometries of treatment sites. A loss of CTV coverage for the electron plans (D , D ) was recorded up to 45%, when curvature of the applicator increased over 30°. Values for D2 cm for both plans were comparable, and they were in range of ±8% of prescription dose. An increase in higher doses (D0.5 cm and D0.1 cm ) was observed in HDR-BT plans, and it was greater for larger lesions. The aveorgans-at-risk (OARs), at a depth or at a lateral distance from CTV. 3D printing has become a popular and widely available technique of rapid prototyping. The impact of used materials on the dose distribution has been studied for high energy sources. However, brachytherapy sources emit lower energy photons, and materials used in 3D printing may differ. This study was conducted to analyze the influence of common materials (polylactic acid - PLA and acrylonitrile butadiene styrene - ABS) used in stereolithography. A 3D-printed phantom was designed, printed, and used to calibrate Gafchromic films. In the next step, a range of 1 mm thick plates of PLA and ABS (from zero to thirty) were inserted between source and detector to measure the impact of studied materials on delivered dose. Measurements were performed using a calibrated radiochromic film and Farmer ionization chamber in water. No statistically significant correlation

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