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https://www.selleckchem.com/products/bms-986165.html Skin diseases have become a global concern. This study aims to evaluate the associations between ambient air pollution and emergency room visits for skin diseases under the background of improving air quality in China. Based on 45,094 cases from a general hospital and fixed-site monitoring environmental data from 2014-2019 in Beijing, China, this study used generalized additive models with quasi-Poisson regression to estimate the exposure-health associations at lag 0-1 to lag 0-7. PM2.5 and NO2 exposure were associated with increased emergency room visits for total skin diseases (ICD10 L00-L99). Positive associations of PM2.5, PM10, O3 and NO2 with dermatitis/eczema (ICD-10 L20-30), as well as SO2 and NO2 with urticaria (ICD-10 L50) visits were also found. For instance, a 10 μg/m3 increase in PM2.5 was associated with increases of 0.7% (95%CI 0.2%, 1.2%) in total skin diseases visits at lag 0-5 and 1.1% (95%CI 0.6%, 1.7%) in dermatitis/eczema visits at lag 0-1, respectively. For PM2.5, PM10 and CO, stronger annual associations were typically observed in the high-pollution (2014) and low-pollution (2018/2019) years. For instance, a 10 μg/m3 increase in PM2.5 at lag 0-5 was associated with increases of 1.8% (95%CI 1.0%, 2.6%) and 2.3% (95%CI 0.4%, 4.3%) in total skin disease visits in 2014 and 2018, respectively. Our study emphasizes the necessity of controlling the potential health hazard of air pollutants on skin, although significant achievements in air quality control have been made in China.(1) Background Chronic inflammation has been regarded as a risk factor for the onset and progression of human cancer, but the critical molecular mechanisms underlying this pathological process have yet to be elucidated. (2) Methods In this study, we investigated whether interleukin (IL)-17-mediated inflammation was involved in cigarette smoke-induced genomic instability. (3) Results Higher levels of both IL-17 and the DNA da

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