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https://www.selleckchem.com/products/OSI-906.html Corresponding results for the high-energy collimator are -15 % to -31 %. The corresponding Monte Carlo simulations show standard deviations of a few percentage points. For the anthropomorphic phantom, before application of recovery coefficients the bias ranges from -16 % to -46 % (medium-energy collimator) and -10 % to -28 % (high-energy collimator), with standard deviations of 2 % to 14 % and 1 % to 16 %. After the application of recovery coefficients, the biases range from -3 % to -35 % (medium energy collimator) and from 0 % to -18 %. The errors decrease with increasing concentrations. Activity-concentration estimation of223Ra with SPECT is feasible, but problems with repeatability need to be further studied. Creative Commons Attribution license.The physical range uncertainty limits the exploitation of the full potential of charged particle therapy. In this work we face this issue aiming to measure the absolute Bragg peak position in the target. We investigate p,4He,12C and16O beams accelerated at the Heidelberg Ion-Beam Therapy Center. The residual range of the primary12C ions is measured using the prompt gamma spectroscopy method, which was demonstrated for proton beams accelerated by cyclotrons and is developed here for the first time for heavier ions accelerated by a synchrotron. We develop a detector system that includes (i) a spectroscopic unit based on cerium(III) bromide and bismuth germanium oxide scintillating crystals, (ii) a beam trigger based on an array of scintillating fibers and (iii) a data acquisition system based on a FlashADC. We test the system in two different scenarios. In the first series of experiments we detect and identify 19 independent spectral lines over a wide gamma energy spectrum in presence of the four ion species for different targets, including also a water target with a titanium insert. In the second series of experiments we introduce a collimator aiming to relate the spectral

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