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https://www.selleckchem.com/products/CP-690550.html Biomass utilization, even for conversion products like hydrochar or biochar, has an increasing demand because improper disposal can cause intensive pollution. In this study, hydrochar obtained by hydrothermal treatment of corn stalk was added to virgin asphalt as a novel modifier by manual stirring and high-speed shearing. This hydrochar-modified asphalt (HCMA) showed a better high-temperature performance compared to unmodified asphalt, and the optimized dosage was 6 wt% with Rutting Index reaching 76 °C, and its penetration and softening point reaching 31.70 (0.1 mm) and 54.70 °C, respectively. The macroscopic representation of modified asphalt was conducted by microscopic characterization methods such as Fourier Transform Infrared Spectroscopy (FTIR) and Gel Permeation Chromatography (GPC). It was demonstrated that the performance was improved by the good blending state between hydrochar and asphalt. The application of hydrochar in modifying asphalt can reduce pollution and enhance its high-temperature performance, which has a potentially extensive application prospect in pavement engineering in subtropical and tropical climate.Psoriasis is linked to systemic inflammation and cardiovascular comorbidities, but studies of the underlying cellular mechanisms are lacking. The NLRP3 inflammasome is genetically associated with psoriasis, and its activation is increasingly linked with cardiovascular disease. In this study, we show that patients with psoriasis exhibited higher plasma levels of inflammasome-generated IL-1β and IL-18, without any correlation to skin lesion severity. Increased constitutive expression of the inflammasome sensors NLRP3, NLRP1, and AIM2 was found in peripheral blood cells of the patients and also of those with mild disease, and this was accompanied by an increased caspase-1 reactivity in the myeloid blood subsets. TNF-α was found to activate selectively the NLRP3 inflammasome without the requir

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