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https://www.selleckchem.com/products/ca77-1.html . The levels of hsCRP correlated with duration of diabetes and HbA1c. Routine screening for future cardiovascular events in diabetes patients can be done with best cut-off value of hsCRP at 1.21 mg/L. Leptin levels are increased in obesity and have been found to be strongly associated with obesity, increased risk of cardiovascular diseases and morbidity. While, carotid intima-media thickness (CIMT) is measured to predict atherosclerosis in early phase. Thus, the objective of this study was to evaluate the leptin levels and CIMT in overweight and obese individuals. This cross-sectional study involving 95 subjects, was performed over a period of 1 year in the Department of Medicine, King George's Medical University, Lucknow. Anthropometric measurements included weight, height, waist circumference (WC), and BMI (Kg/m2). Baseline investigations were fasting blood glucose and lipid profile. Quantitative estimation of leptin was done by leptin ELISA, and CIMT was measured using a high-resolution B-mode ultrasound scanner with a 7 MHz linear transducer. Unpaired t-test or ANNOVA was used to compare quantitative variables, and chi-square or fisher's exact test was used to compare categorical variables. Pearsondy indicates that overweight and obesity results in significant increase in both leptin levels and CIMT values. Furthermore, increased leptin levels and CIMT values are positively correlated with increase in BMI and WC. Endoscopic Sleeve gastroplasty (ESG) is a novel minimally invasive endoscopic restrictive bariatric procedure. We studied the safety, effectiveness, 6-month weight loss outcomes of ESG. We prospectively collected data for patients undergoing ESG at a tertiary care referral center. Laboratory investigations were performed preoperatively, and at 6 months post-operatively. Anthropometric measurements were noted pre and post-operatively at a frequency of 3 months for a 6-month follow-up. Patients with BMI ≥28

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