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https://www.selleckchem.com/products/E7080.html Depleted uranium (DU) is an emerging heavy metal pollutant with considerable environmental and occupational concerns. Its radiotoxicity is known to be low. However, its chemical toxicity should not be ignored. In order to explore the chemical toxicity of DU, the effects of uranyl nitrate, prepared from DU, on the model organism Caenorhabditis elegans were investigated. Chronic exposure to DU did not affect the lifespan or reproduction of the worm. DU had little effect on the physiological processes of C. elegans. Additionally, DU treatment did not make C. elegans more susceptible to UV, heat, or oxidative stress. Interestingly, chronic exposure of DU decreased the in vivo reactive oxygen species-scavenging ability through inhibiting the expression of antioxidant genes ctl-1, ctl-2, ctl-3, gst-7, and gst-10. Chronic but not acute exposure of DU induced a statistically significant degeneration of the dopaminergic (DAergic) neurons of treated worms and promoted the increase of α-synuclein aggregation and DAergic neurotoxicity. These findings may raise the public concerns regarding DU as an etiologic agent of Parkinson's disease and underline its potential neurotoxicity.Regulating the states of hydrogen bonds in ionic liquids (ILs) is an effective way to improve their catalytic performance. In this paper, disulfonic-functionalized acidic ionic liquids (DSFAILs) were synthesized successfully, including novel SO3H-functionalized binuclear IL (bis[3-(CH2)3SO3H-1-(CH2)2-Im][HSO4]2). For the biodiesel synthesis, compared with the traditional ILs catalysts, DSFAILs bis[(3-(CH2)3SO3H-1-(CH2)2-Im][HSO4]2, [Im(N (CH2)3SO3H)2][HSO4]) had higher catalytic activity even under mild reaction conditions. Using the density functional theory (DFT) method, the role of hydrogen bonds in different SO3H-functionalized acidic ionic liquids (SFAILs) was explored. The forms of hydrogen bonds existing in different ILs directly determine their acid

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