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https://www.selleckchem.com/products/leukadherin-1.html nd clinically-relevant perspective is that it can reveal drug-drug interactions (DDIs) due to unexpected regulation of hepatic transporters, and enable prediction of altered PK and PD changes, especially for tissue concentration-based DDIs. The American Society for Pharmacology and Experimental Therapeutics.BACKGROUND Differentiating between pneumonia and acute bronchitis is often difficult in primary care. There is no consensus regarding clinical decision rules for pneumonia, and guidelines differ between countries. Use of diagnostic tests and change of management over time is not known. AIM To calculate the proportion of diagnostic tests in the management of lower respiratory tract infections (LRTIs) in a low antibiotic prescribing country, and to evaluate if the use and prescription pattern has changed over time. DESIGN & SETTING A register-based study on data from electronic health records from January 2006 to December 2014 in the Kronoberg county of south east Sweden. METHOD Data regarding use of C-reactive protein (CRP), chest x-rays (CXRs), microbiological tests, and antibiotic prescriptions were assessed for patients aged 18-79 years, with the diagnosis pneumonia, acute bronchitis, or cough. RESULTS A total of 54 229 sickness episodes were analysed. Use of CRP increased during the study period from 61.3% to 77.5% for patients with pneumonia (P less then 0.001), and from 53.4% to 65.7% for patients with acute bronchitis (P less then 0.001). Use of CXR increased for patients with acute bronchitis from 3.1% to 5.1% (P less then 0.001). Use of microbiological tests increased for patients with pneumonia, from 1.8% to 5.1% (P less then 0.001). The antibiotic prescription rate decreased from 18.6 to 8.2 per 1000 inhabitants per year for patients with acute bronchitis, but did not change for patients with pneumonia. CONCLUSION Use of CRP and microbiological tests in the diagnostics of LRTIs increased despite th

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