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https://www.selleckchem.com/products/PHA-739358(Danusertib).html 79 g/L malic acid accumulation from sole methanol feeding with nitrogen source optimization. These results will provide guidance and reference for the metabolic engineering of P. pastoris to produce value-added chemicals from methanol. was to assess the misperception of visual verticality (VV) in patients with peripheral vestibular disorders (PVD) in comparison with healthy controls. As secondary objectives, we checked if vestibular, visual, and somatosensory postural pathways can be affected in patients with PVD as well as the characteristics of PVD that could influence on the VV perception. A systematic review with meta-analysis was carried out. The bibliographic search was performed in January, 2020 in PubMed, Scopus, Web of Science (WOS), CINAHL, SciELO. Two reviewers selected the studies that met the inclusion criteria, extracted data, and assessed the methodological quality using the Newcastle-Ottawa Scale (NOS). The VV perception was assessed in two meta-analysis according the used test The Subjective Visual Vertical test (SVV) or the Rod and Frame Test (RFT) in comparison with healthy subjects. The Standardized Mean Difference (SMD) and its 95% Confidence Interval (95% CI) was used to estimate the pooled effect. Publication bias was assessed using the Egger's test and Trim and Fill Method. Thirty-four studies were included reporting 3,524 participants. #link# PVD patients showed a misperception of the VV with SVV (SMD = 1.510; 95%CI 1.190-1.830) and the RFT (SMD = 0.816; 95% CI 0.234-1.398) respect healthy controls. A subgroup of patients in the acute phase (SMD = 2.5; 95%CI 2.022-2.978) and who underwent a vestibular surgery (SMD = 2.241; 95%CI 1.471-3.011) had the greater misperception of VV. Patients with PVD show an alteration in the perception of VV, being greater in the acute phase and after a vestibular surgery. Laryngoscope, 2020. Patients with PVD show an alteration in the perception o

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