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https://www.selleckchem.com/products/piceatannol.html Distributed transient contractions and MMs yield a balanced dynamic plastic state of the regions of the bladder wall. An almost constant detrusor pressure can be attributed to the active accommodation of detrusor pressure to changes in bladder volume. Localized contractile activity and MMs that change the plastic elongated state of varying bladder regions are biomechanically effective in the active accommodation of detrusor pressure to changes in bladder volume. According to this concept, autonomous bladder wall activity as a source of nerve activity, also is crucial for active accommodation. Localized contractile activity and MMs that change the plastic elongated state of varying bladder regions are biomechanically effective in the active accommodation of detrusor pressure to changes in bladder volume. According to this concept, autonomous bladder wall activity as a source of nerve activity, also is crucial for active accommodation. L-carnitine is an amino acid derivative that is thought to be helpful for treating renal anemia in hemodialysis patients. However, the mechanism remains to be fully elucidated. A literature search was performed on PubMed, Embase, and Cochrane Central Register of Controlled Trials to identify randomized controlled trials (RCTs) and conduct a meta-analysis for investigating the effect of L-carnitine in the treatment of renal anemia in participants receiving hemodialysis. A total of 18 eligible trials with 1090 participants were included in this study. L-carnitine can significantly increase plasma free L-carnitine levels (mean difference [MD] 140.53, 95% confidence interval [CI] 102.22-178.85; P < 0.00001), decrease the erythropoietin responsiveness index (ERI; MD -2.72, 95% CI -3.20 to -2.24; P < 0.00001) and the required erythropoiesis-stimulating agent (ESA) doses (MD -1.70, 95% CI -2.04 to -1.36; P < 0.00001). However, the use of L-carnitine was not associated with a higher hemoglob

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