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https://www.selleckchem.com/products/sn-011-gun35901.html Results Postoperative PALT and BVRT were significantly lower than preoperative PALT and BVRT in the conventional anaesthesia group (P-value = 0.043, P-value = 0.015 respectively), but not in the Mg sulphate group (P-value = 0.134, P-value = 0.151 respectively). Postoperative S100B was significantly higher than preoperative S100B in the conventional anaesthesia group (P-value = 0.006), but not in the Mg sulphate group (P-value = 0.293). Conclusions Administration of intravenous infusion of magnesium sulphate during conventional general anaesthesia can protect against POCD and attenuate the post operative elevation of serum S100B.Background Ventilator-associated pneumonia (VAP) is a significant cause of morbidity and mortality in critically ill patients who require mechanical ventilation (MV). Subglottic secretions above the endotracheal cuff are associated with bacteria colonization of lower respiratory tract, causing VAP. A preventive strategy to avoid subglottic secretion progression is the drainage with special tracheal tubes effective in preventing both early onset and late onset VAP. The purpose of this study was to measure VAP incidence in tracheostomized patients with suction above the cuff. Methods Study design - matched cohort study with historical control in three academic ICUs upon ICU admission, patients requiring MV were submitted to tracheostomy with a tracheal tube allowing drainage of subglottic secretions (treatment group). A control group without suctioning above the cuff was selected applying the propensity score matching on dataset of previous ELT study. VAP occurrence at 28-days from intubation was the primary endpoint; hospital mortality and ICU-free days at 28-days were the secondary endpoints. Results Between July 2014 and April 2016, 125 tracheostomized patients were included in the analysis. 232 tracheostomized patients without suctioning were selected as a control group for the match

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