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https://www.selleckchem.com/products/mg149.html The sensitising effect of ORI on FLC in the treatment of C. albicans also included the promotion of apoptosis. We demonstrated that combining azoles with ORI exerted potent synergism and that ORI could promote sensitisation to azoles in azole-resistantC. albicans. The discovery that ORI can effectively inhibit drug efflux and promote apoptosis may provide new insights and therapeutic strategies to overcome increasing azole resistance in C. albicans. We demonstrated that combining azoles with ORI exerted potent synergism and that ORI could promote sensitisation to azoles in azole-resistantC. albicans. The discovery that ORI can effectively inhibit drug efflux and promote apoptosis may provide new insights and therapeutic strategies to overcome increasing azole resistance in C. albicans. To evaluate the bleaching efficacy of a violet radiation (VR) combined or not with bleaching gels on the color and mineral content of stained teeth. Enamel/dentin blocks were obtained and stained (n = 50) with coffee, red wine, tobacco smoke, or were left non-stained. The stained or not-stained blocks (n = 10) were distributed into five bleaching groups (n = 10) VR, CP (37 % carbamide peroxide), VR/CP, HP (35 % hydrogen peroxide), and VR/HP. Color (ΔE ΔL, Δa, and Δb) and whiteness index (ΔWI ) changes were evaluated after staining and after bleaching using a spectrophotometer. Calcium (Ca), phosphorous (P), and Ca/P contents (in wt%) were measured after bleaching using energy-dispersive X-ray spectroscopy (EDS). Data was statistically analyzed (α = 0.05) using two-way ANOVA and Tukey tests (ΔE ΔWI , ΔL, Δb, wt%) or Kruskal-Wallis and Dunn tests (Δa). VR alone caused higher colorimetric changes on coffee, tobacco and red wine-stained groups compared to non-stained enamel (p < 0.05). VR/CP exhibited higher colorimetric changes compared to CP in coffee and non-stained groups. The VR/CP, HP and VR/HP groups exhibited no change differences (p

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