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https://www.selleckchem.com/products/MK-2206.html Turner syndrome (TS) is a chromosomal condition that affects development in females. The case of TS in the mother whose child was diagnosed with acute leukemia at the age of 1.5 years is presented. FANCI gene in child was detected among 94 genes associated- with hematologic malignancies. Acute lymphoblastic leukemia, common-B ІІ, L1, associated with t(12;21)(p13;q22), TEL/AML1 (ETV6/RUNX1) in a child was detected during a prophylactic examination. During the treatment of the baby, the mother had a second pregnancy, which ended in miscarriage at 8 weeks. Upon cytogenetic examination in the mother TS was revealed - mos45,Х[23]/46, ХХ[7], and the father's karyotype was without abnormalities (46, ХУ). After chemotherapy, the child is in clinical-hematological remission. It could be suggested that chromosomal abnormalities in mother with TS may cause the chromosomal instability and hematological malignancy in offspring. Previous studies have pointed out the role of dickkopf-related protein 1 (DKK1)- Wnt inhibitor, which is essential for osteoblast functioning, in the development of osteolytic lesions in multiple myeloma (MM). To assess the DKK1expression displayed by myeloma cells in bone marrow trephine biopsies of patients with and without osteolytic lesions, and in different malignancy grades of the disease. The expression level of DKK1was assessed immunohistochemically in bone marrow of 49MM patients presented with and without osteolytic lesions (the 1 and the 2 group, respectively). Levels of weak, moderate, and strong DKK1expression were distributed- as 43.33, 27.78and 25.56%, and 63.91, 18.80, and 1.50%, respectively when evaluating the samples obtained from the 1 and the 2 group. Statistically significant differences were found when the levels of DKK1expression in the 1 and the 2 group were compared (χ = 51; df= 3; p< 0.001). DKK1contributes to the development of osteolytic lesions in MM. The present study provide

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