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https://www.selleckchem.com/products/torin-2.html The single-tone sound source localization (SSL) by majority of fly Ormia ochracea's ears-inspired directional microphones leaves a limited choice when an application like hearing aid (HA) demands broadband SSL. Here, a piezoelectric MEMS directional microphone using a modified mechanical model of fly's ear has been presented with primary focus to achieve SSL in most sensitive audio bands to mitigate the constraints of traditional SSL works. In the modified model, two optimized rectangular diaphragms have been pivoted by four optimized torsional beams; while the backside of the whole structure has been etched. As a result, the SSL relative to angular rotation of the incoming sound depicts the cosine dependency as an ideal pressure-gradient sensor. At the same time, the mechanical coupling leads the magnitude difference between two diaphragms which has been accounted as SSL in frequency domain. The idea behind this work has been analytical simulated first, and with the convincing mechanical results, the designehich are the lowest ever reported by a similar device. With the developed SSL in broadband-in addition to the lowest noise-the developed device can be extended in some audio applications like an HA device.Four anthraquinone derivatives, termstrin A, B, C and D (1-4), were isolated and purified from termite-associated Streptomyces sp. BYF63. Their structures were elucidated on the basis of extensive spectroscopic analyses (HR-ESI-MS, 1D and 2D NMR). Compounds 1 and 4 were found to possess potent antibacterial activities against Staphylococcus aureus, with the zone of inhibition (ZOI) values of 12.85 and 11.17 mm, respectively, which were comparable to that of penicillin sodium with ZOI of 13.15 mm. Furthermore, metabolite 1 showed moderate cytotoxicities against melanoma cell line A375 and gastric cancer cell line MGC-803, with IC50 values of 22.76 and 36.65 μM, respectively, which were less than those of referenc

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