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001). There was a significant difference in mean scores for knowledge and attitude before and after the intervention, whereas no significant findings noted for practices ( <0.001). Be SAFE booklet contributed to the increase in parents/guardian's knowledge and attitudes towards drowning prevention and water safety to prevent the risk of child drowning. Be SAFE booklet contributed to the increase in parents/guardian's knowledge and attitudes towards drowning prevention and water safety to prevent the risk of child drowning. To study the effects of long non-coding ribonucleic acid (lncRNA) HOX transcript antisense intergenic RNA (HOTAIR) on the proliferation and apoptosis of malignant melanoma cells, and to explore its specific regulatory mechanism through the nuclear factor-kappa B (NF-ϰB) signaling pathway. LncRNA HOTAIR small-interfering RNAs (siRNAs) were designed and synthesized, and the effects of si-HOTAIR transfection on the proliferation and apoptosis of malignant melanoma cells were detected via cell counting kit-8 (CCK-8) assay, 4',6-diamidino-2-phenylindole (DAPI) staining assay and flow cytometry, respectively. The gene expressions were determined using quantitative reverse transcription-polymerase chain reaction (qRT-PCR), the changes in NF-ϰB pathway-related proteins and apoptosis-associated proteins after interference in lncRNA HOTAIR were detected via Western blotting, and the level of NF-ϰB in each group was determined via ELISA. The results of CCK-8 assay revealed that the cell proliferation rate significantly declined gradually in si-HOTAIR group compared with that in si-NC group and control group ( <0.05). The results of Western blotting and ELISA showed that the activity of NF-ϰB in si-HOTAIR group was weakened ( <0.05), suggesting that down-regulation of HOTAIR can suppress the activity of NF-ϰB. Compared with si-NC group and control group, si-HOTAIR group had remarkably increased gene and protein expressions of pro-apoptotic Bax, and remarkably decreased gene and protein expressions of anti-apoptotic Bcl-2 ( <0.05), demonstrating that down-regulation of HOTAIR can promote apoptosis. Down-regulation of lncRNA HOTAIR can inhibit the proliferation and promote the apoptosis of malignant melanoma cells and suppress the NF-ϰB pathway. Down-regulation of lncRNA HOTAIR can inhibit the proliferation and promote the apoptosis of malignant melanoma cells and suppress the NF-ϰB pathway. Dermatophytosis is one of the most common fungal infections in humans. Antifungals such as fluconazole are effectively used for treating dermatophytosis; however, drug resistance was observed in many cases. Therefore, a newer treatment strategy is essential. This study (Conducted in the Laboratory of the School of Public Health, Tehran University of Medical Sciences, Tehran, Iran in 2018) evaluated the antifungal susceptibility of nano fluconazole compared to conventional fluconazole on dermatophyte isolates using CLSI M38-A2guidelines. Dermatophyte species isolated from clinical cases of dermatophytosis were identified using PCR sequencing techniques. Zeta potential and size of the nano particles containing fluconazole were measured; scanning electron microscope (SEM) was used to determine nano particle structure. The size of liposomal fluconazole obtained was 88.9 ± 12.14 nm with -20.12 ± 3.8 mV for zeta potential. The encapsulation rate for fluconazole was 75.1± 4.2%. MIC for the three tested species was 32, 16, and 8 g/ml for , , and isolates, respectively. The corresponding values for nano fluconazole were 8 g/ml for the three tested species. MIC value for nano-fluconazole was lower than conventional fluconazole in all dermatophytes species tested; therefore, nano-fluconazole could inhibit the growth of dermatophytes better than fluconazole at a lower concentration of the drug. MIC value for nano-fluconazole was lower than conventional fluconazole in all dermatophytes species tested; therefore, nano-fluconazole could inhibit the growth of dermatophytes better than fluconazole at a lower concentration of the drug. We aimed to focus on a review of the literature on physical activity and physical fitness for children and adolescents in Montenegro, to identify and evaluate the current situation and provide a better basis for the creation of a future monitoring system. The Montenegrin Research Team (MRT) has set up a specific methodology that is reflected in the assessment of physical activity and physical fitness of Montenegrin children and adolescents through ten separate indicators. Grades were awarded based on data found in available scientific articles that were published up to 2018, as well as in the grey literature, such as government and nongovernment reports and online content from the same period. All indicators averaged 3.7 on a six-point scale. It is interesting to note that two indicators were rated as excellent, three more indicators were rated with above-average, four indicators were rated as below-average and, lastly, one indicator was rated as "unfinished". Children's and adolescents' physical activity and physical fitness for Montenegro might be good, especially if compared to other countries from the region. Children's and adolescents' physical activity and physical fitness for Montenegro might be good, especially if compared to other countries from the region. The population attributable risk (PAR) percent has used widely in public health policy. https://www.selleckchem.com/products/Perifosine.html We aimed to calculate the attribute risk of hypertension due to hyperuricemia by Levin's formulas compare to direct PAR calculation method. This was a sub-study of Yazd Healthy Heart Cohort (YHHC). Overall, 1256 normotensive individuals were enrolled through multistage randomized cluster sampling and followed up for mean 9.8 years, from 2005-2015. The threshold cutoff point of the hyperuricemia was considered equal and more than 75 percentile that equal to 5.5 mg/dl for men and 4.3mg/dl for women. To calculate the attributable risk of hyperuricemia in developing hypertension, two methods were applied. Levin's formulas and direct PAR estimation by population risk calculation via exposure prevalence weighted formula. Multiple logistic regression was used for estimate of odds ratio (OR) of hyperuricemia in developing hypertension. We calculated Relative Risk (RR) from OR. The data were analyzed using SPSS software version 16.
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