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https://www.selleckchem.com/products/nms-873.html Foam films formed at the air-water interface do not have fixed adsorption sites where adsorbed surfactants can arrange themselves, resulting in the formation of thick adsorption layers. Current theories of equilibrium foam films fail to account for this feature and significantly underestimate the adsorption layer thickness. Here we show that this thickness has a significant effect on the disjoining pressure in foam films. If ignored, the theory predicts unphysical electrostatic potential profiles, which underestimate the disjoining pressure. We apply a previously developed adsorption model that incorporates a realistic thickness for the adsorption layer. This new model reproduces experimental measurements of the disjoining pressure of foam films very well over a wide surfactant concentration range without fitting parameters. Our work shows that a thick adsorption layer is less effectively screened by counterions, resulting in a higher electrostatic potential inside the film and therefore a higher disjoining pressure.Hairpin ribozyme catalyzes the reversible self-cleavage of phosphodiester bonds which plays prominent roles in key biological processes involving RNAs. Despite impressive advances on ribozymatic self-cleavage, critical aspects of its molecular reaction mechanism remain controversially debated. Here, we generate and analyze the multidimensional free energy landscape that underlies the reaction using extensive QM/MM metadynamics simulations to investigate in detail the full self-cleavage mechanism. This allows us to answer several pertinent yet controversial questions concerning activation of the 2'-OH group, the mechanistic role of water molecules present in the active site, and the full reaction pathway including the structures of transition states and intermediates. Importantly, we find that a sufficiently unrestricted reaction subspace must be mapped using accelerated sampling methods in order to comput

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