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https://www.selleckchem.com/products/sodium-l-lactate.html Previously, high-aspect- ratio ribbon-like microconfetti (MC) composed of acetalated dextran (Ace-DEX) have been shown to form a subcutaneous depot for sustained drug release. In this study, MC were explored as an injectable vaccine platform. Production of MC by electrospinning followed by high-shear homogenization allowed for precise control over MC fabrication. Three distinct sizes of MC, small (0.67 × 10.2 μm2), medium (1.28 × 20.7 μm2), and large (5.67 × 90.2 μm2), were fabricated and loaded with the adjuvant, resiquimod. Steady release rates of resiquimod were observed from MC, indicating their ability to create an immunostimulatory depot in vivo. Resiquimod-loaded MC stimulated inflammatory cytokine production in bone marrow-derived dendritic cells without incurring additional cytotoxicity in vitro. Interestingly, even medium and large MC were able to be internalized by antigen-presenting cells and facilitate antigen presentation when ovalbumin was adsorbed onto their surface. After subcutaneous injection in vivo with adsorbed ovalbumin, blank MC of all sizes were found to stimulate a humoral response. Adjuvant activity of resiquimod was enhanced by loading it into MC and small- and medium-sized MC effectively induced a Th1-skewed immune response. Antigen co-delivered with adjuvant-loaded MC of various sizes illustrates a new potential vaccine platform.Typically, the optical applications of silicon (Si) are limited to wavelengths below ∼1100 nm. However, there is significant research on Si surface modification, which tries to extend the optical properties of Si further into the infrared (IR) region. In this work, we present an ultra-wideband complementary metal-oxide-semiconductor (CMOS)-biocompatible Si-based optical absorber with a hydrophobic surface. It consists of patterned three-dimensional grid-like structures of optimized compounds of titanium (Ti) on n-type Si (n-Si). Here, the Ti-compounds on

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