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https://www.selleckchem.com/products/ITF2357(Givinostat).html When opinions in a society change toward more or less tolerance of a group, people do not necessarily see it. Drawing on a quasi-representative survey (Study 1, N = 830) and a natural experiment (Study 2, N = 437), we investigated people's perceptions of the societal norms toward sexual minorities and the influence of laws on these (mis-)perceptions. Study 1 indicated pluralistic ignorance as participants overestimated the societal disapproval toward same-sex issues. Complementing this finding, Study 2 found that informing participants about a new law legalizing stepchild adoption decreased perceived societal disapproval of same-sex parenting compared with participants not informed about the law. Pluralistic ignorance, however, was not affected by the new law. While results indicate that pluralistic ignorance may be more resilient to change, they also highlight that laws can have a dual impact on societies, changing not only the legal situation but also shifting perceptions of societal norms.Aim This study provides clinicians and researchers with an informed choice between current commercially available targeted sequencing panels and exome sequencing panels in the context of pan-cancer pharmacogenetics. Materials & methods Nine contemporary commercially available targeted pan-cancer panels and the xGen Exome Research Panel v2 were investigated to determine to what extent they cover the pharmacogenetic variant-drug interactions in five available cancer knowledgebases, and the driver mutations and fusion genes in the Cancer Genome Atlas. Results xGen Exome Research Panel v2 and TrueSight Oncology 500 target 71.0 and 68.9% of the pharmacogenetic interactions in the available knowledgebases; and 93.7 and 86.0% of the driver mutations in the Cancer Genome Atlas, respectively. All other studied panels target lower percentages. Conclusion Exome sequencing outperforms pan-cancer targeted sequencing panels in term
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