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https://www.selleckchem.com/products/alexidine-dihydrochloride.html Survival analysis is a widely used method to establish a connection between a time to event outcome and a set of potential covariates. Accurately predicting the time of an event of interest is of primary importance in survival analysis. Many different algorithms have been proposed for survival prediction. However, for a given prediction problem it is rarely, if ever, possible to know in advance which algorithm will perform the best. In this paper we propose two algorithms for constructing super learners in survival data prediction where the individual algorithms are based on proportional hazards. A super learner is a flexible approach to statistical learning that finds the best weighted ensemble of the individual algorithms. Finding the optimal combination of the individual algorithms through minimizing cross-validated risk controls for over-fitting of the final ensemble learner. Candidate algorithms may range from a basic Cox model to tree-based machine learning algorithms, assuming all candidate algorithms are based on the proportional hazards framework. The ensemble weights are estimated by minimizing the cross-validated negative log partial likelihood. We compare the performance of the proposed super learners with existing models through extensive simulation studies. In all simulation scenarios, the proposed super learners are either the best fit or near the best fit. The performances of the newly proposed algorithms are also demonstrated with clinical data examples.BACKGROUND Exergames have the potential to provide an accessible, remote approach for post stroke upper extremity (UE) rehabilitation. However, the use of exergames without any follow-up by a health professional could lead to compensatory movements during the exercises, inadequate choice of difficulty level, exercises not being completed and lack of motivation to pursue exercise program, thereby decreasing their benefits. Combining t

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