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https://www.selleckchem.com/ Objective To explore the effects of curcumin (CCM) on tumor growth and immune function in mice bearing RM-1 prostate cancer cells. METHODS A prostate cancer model was established in 50 C57BL/6 mice by subcutaneous inoculation of RM-1 cells. The model mice were randomly assigned to intraperitoneal injection of 10% dimethyl sulfoxide at 0.2 ml (the model control group), cyclophosphamide at 20 mg/kg (the CTX group), or CCM at 50 mg/kg (the low-dose CCM group), 100 mg/kg (the medium-dose CCM group) or 200 mg/kg (the high-dose CCM group), respectively, all once a day for 14 successive days, followed by measurement of the tumor weight, calculation of the tumor-inhibition rate, and detection of immunological indicators. RESULTS The tumor weight was significantly decreased in the CTX (［1.32 ± 0.06］ g), low-dose CCM (［1.1.54 ± 0.08］ g), medium-dose CCM (［1.48 ± 0.08］ g), and high-dose CCM groups (［1.42 ± 0.07］ g) as compared with that in the model control group (［2.09 ± 0.10］ g) (P 0.05). The tumor-inhibition rates in the CTX and low-, medium- and high-dose CCM groups were 36.84%, 27.27%, 29.18% and 32.06%, respectively. All the immunological indicators except the CD4+/CD8+ ratio were remarkably reduced in the CTX group as compared with those in the model control (P less then 0.01), but increased in the CCM groups in comparison with those in the CTX group (P less then 0.01). CONCLUSIONS Curcumin has an anti-tumor effect and enhances immune function in prostate cancer-bearing mice.Objective To study the effect of a new human sperm freezing method on the sperm recovery rate and search for an optimal method for cryopreservation of human epididymal sperm. METHODS We collected semen samples from 76 men with obstructive azoospermia by percutaneous epididymal sperm aspiration and divided each sample into two parts to be cryopreserved with a self-made metal freezing plate (the experimental group) or by slow freezing (the control group), respectively. We

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