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https://www.selleckchem.com/products/apx2009.html The stability of synchronised networked systems is a multi-faceted challenge for many natural and technological fields, from cardiac and neuronal tissue pacemakers to power grids. For these, the ongoing transition to distributed renewable energy sources leads to a proliferation of dynamical actors. The desynchronisation of a few or even one of those would likely result in a substantial blackout. Thus the dynamical stability of the synchronous state has become a leading topic in power grid research. Here we uncover that, when taking into account physical losses in the network, the back-reaction of the network induces new exotic solitary states in the individual actors and the stability characteristics of the synchronous state are dramatically altered. These effects will have to be explicitly taken into account in the design of future power grids. We expect the results presented here to transfer to other systems of coupled heterogeneous Newtonian oscillators.Rewiring cellular sensors to trigger non-natural responses is fundamental for therapeutic cell engineering. Current designs rely on engineered receptors that are limited to single inputs, and often suffer from high leakiness and low fold induction. Here, we present Generalized Engineered Activation Regulators (GEARs) that overcome these limitations by being pathway-specific rather than input-specific. GEARs consist of the MS2 bacteriophage coat protein fused to regulatory or transactivation domains, and work by rerouting activation of the NFAT, NFκB, MAPK or SMAD pathways to dCas9-directed gene expression from genomic loci. This system enables membrane depolarization-induced activation of insulin expression in β-mimetic cells and IL-12 expression in activated Jurkat cells, as well as IL-12 production in response to the immunomodulatory cytokines TGFβ and TNFα in HEK293T cells. Engineered cells with the ability to reinterpret the extracellular milieu have potential

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