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https://www.selleckchem.com/products/bi-4020.html Sexual communication offers relational and sexual benefits. However, the sexual communication occurring in an individual's relationship may be incongruent with their expectations for such communication. Such discrepancies can affect partners' relationships and are important to examine. This study presents a new instrument for assessing discrepancies in sexual communication, the Sexual Communication Discrepancy Index (SCDI). Results of two studies examining SCDI's dimensionality, factor structure, and reliability revealed a promising 24-item, 4-factor scale instrument. The index offers a brief, easily scored, and reliable measure of sexual communication discrepancies. It may prove useful for researchers and clinicians who focus on sexual communication.Radiotherapy (RT) is a frequently used means in clinical tumor treatment. The outcome of RT varies, however, to a great extent, due to RT resistance or intolerable dose, which might be resolved by the development of radio-sensitizing strategies. Here, we report redox-sensitive iodinated polymersomes (RIP) carrying histone deacetylase inhibitor, suberoylanilide hydroxamic acid (SAHA, vorinostat), as a new dual-functional nano-radiosensitizer for breast cancer radiotherapy. SAHA-loaded RIP (RIP-SAHA) with a size of about 101 nm exhibited good colloidal stability while the reduction-activated release of SAHA, giving rise to better antitumor effect to 4T1 breast carcinoma cells than free SAHA. Accordingly, RIP-SAHA combined with a 4 Gy dose of X-ray radiation led to significantly enhanced suppression of 4T1 cells compared with SAHA combined 4 Gy of X-ray radiation, as a result of enhanced DNA damage and impeded DNA damage repair. The pharmacokinetics and biodistribution studies by single-photon emission computed tomography (SPECT) with 125I-labeled SAHA (125I-SAHA) showed a 17.3-fold longer circulation and 237.7-fold better tumor accumulation of RIP-SAHA over SAHA. The syste

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