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https://www.selleckchem.com/products/voruciclib.html 8~6.5) were demonstrated by zeta potential change from -23.1 mV to 29.9 mV. The pHe responsive HAase release was confirmed in the tumor extracellular mimicking environments, and the intratumoral biodistribution showed that the tumor penetration of HCLR was improved. The cell uptake of HCLR in pHe environment was significantly enhanced compared with that in physiological pH environment. The increased shRNA release of HCLR was approved in 10 mM glutathione (GSH) and tumor cells. Surprisingly, HCLR suppressed the tumor growth markedly through survivin silencing and meanwhile maintained low toxicity to mice. This study indicates that the novel polysaccharide enveloped HCLR is promising in clinical translation, thanks to the stimuli-triggered tumor accumulation, tumor penetration, cell uptake and intracellular gene release.Despite the ever-growing demand in safe and high power/energy density of Li+ ion and Li metal rechargeable batteries (LIBs), materials-related challenges are responsible for the majority of performance degradation in such batteries. These challenges include electrochemically induced phase transformations, repeated volume expansion and stress concentrations at interfaces, poor electrical and mechanical properties, low ionic conductivity, dendritic growth of Li, oxygen release and transition metal dissolution of cathodes, polysulfide shuttling in Li-sulfur batteries, and poor reversibility of lithium peroxide/superoxide products in Li-O2 batteries. Owing to compelling physicochemical and structural properties, in recent years two-dimensional (2D) materials have emerged as promising candidates to address the challenges in LIBs. This Review highlights the cutting-edge advances of LIBs by using 2D materials as cathodes, anodes, separators, catalysts, current collectors, and electrolytes. It is shown that 2D materials can protect the electrode materials from pulverization, improve the synergy of Li+ ion de

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