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https://www.selleckchem.com/mTOR.html 03±1.06) or CG (5.23±0.72) (p < 0.05). The mean pain scores in HAG (6.80±0.7) and MG (7.30±0.8) during 6-7cm of cervical dilation were significantly lower than that in CG (7.70±0.5) (p < 0.001). Moreover, a statistically significant difference was found between the mean CCQ total scores (HAG 31.06±3.46, CG 27.66±3.85, p < 0.05), mean CCQ physical comfort scores (HAG 13.16±1.89, CG 11.03±1.80, p < 0.001), mean CCQ relief comfort level score (HAG 11.23±1.43, CG 10.00±2.01, p < 0.05) and mean CCQ transcendence comfort level scores (HAG 19.83±2.37, CG 17.66±2.15, p < 0.05) and both HAG and CG during 8-9cm of cervical dilation. Heat application and massage can be used as a safe and effective midwifery intervention to reduce the perception of pain in pregnant women and provide comfort during labor. Heat application and massage can be used as a safe and effective midwifery intervention to reduce the perception of pain in pregnant women and provide comfort during labor. Among the several new targets for the comprehension of the biology of pancreatic ductal adenocarcinoma (PDAC), Prion proteins (PrPc) deserve particular mention, since they share a marked neurotropism. Actually, PrPc could have also a role in tumorigenesis, as recently demonstrated. However, only few invitro studies in cell cultures showed the occurrence of PrPc in PDAC cells. We aim to evaluate the presence of PrPc invivo in PDAC tissues as a potential new biomarker. Samples from tumors of 23 patients undergone pancreatic resections from July 2018 to May 2020at our institution were collected and analyzed. Immunohistochemistry and western blotting of PDAC tissues were compared with control tissues. Immunohistochemistry was used also to evaluate the localization of PrPc and of CD155, a tumoral stem-cell marker. All cases were moderately differentiated PDAC, with perineural invasion (PNI) in 19/23 cases (83%). According to western-blot analysis, PrPc was markedly expressed

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