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https://www.selleckchem.com/ The granule mass was evaluated for the bulk density, tapped density, inter-particle porosity, Carr's index, Hausner ratio, angle of repose, and flowability. RESULTS The results showed that all of the formulae passed the requirement of the preformulation test. The bulk density of the granule mass was 0.79 - 0.86 g/ml; the tapped density was 0.88 - 0.90 g/ml; the inter-particle porosity was 0.03 - 0.14; the Carr's index was 2.71 - 11.94%; the Hausner ratio was 1.09-1.12; the angle of repose was 26.10 - 28.90°; and the flowing time was 5.97 - 6.63 seconds. All of the formulae showed good flowability and free-flowing properties. CONCLUSION It is concluded that the obtained formula containing pugun tano ethanolic extract can be formulated into granule mass for the capsule dosage form. Copyright © 2019 Urip Harahap, Marianne Marianne, Yuandani Yuandani, Lia Laila.Circular RNAs (circRNAs) are involved in cancer development via inhibition of miRNAs, which are associated with differentiation, proliferation, migration, and carcinogenicity. Curcumin has antioxidant and anti-cancer properties, and it has also been used as a radiosensitizer. In this study, we explored the potential relationships among curcumin, circRNAs, and nasopharyngeal carcinoma (NPC). We compared the differences in circRNA levels in NPC cell lines after radiotherapy and after treatment with curcumin, using a high-throughput microarray. Further, a circRNA-miRNA-mRNA interaction network between radiation resistance NPC cell lines and tumor stem cells was constructed by applying bioinformatics. Finally, it was demonstrated by reverse transcription-quantitative polymerase chain reaction assay and wound healing assay that curcumin could enhance radiosensitization of NPC cell lines via mediating regulation of tumor stem-like cells by the "hsa_circRNA_102115"-"hsa-miR-335-3p"-"MAPK1" interaction network. © The author(s).Colorectal cancer (CRC) is one of the most common carcinomas and t
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