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https://www.selleckchem.com/products/escin.html 007), respiratory failure (p = 0.010), and increased mortality (p = 0.02). Receipt of a SOT primarily accounted for increased severity, respiratory failure, and mortality in immunosuppressed patients. SOT recipients had an 18-fold higher annual incidence for blastomycosis than the general population. The rate of disseminated blastomycosis was similar among NIC, SOT, and non-SOT IC. Relapse rates were low (5.3 - 7.7%). CONCLUSIONS Immunosuppression had implications regarding the acuity, severity, and respiratory failure. The rate of dissemination was similar across the immunologic spectrum, which is in sharp contrast to other endemic fungi. This suggests that pathogen-related factors have a greater influence on dissemination for blastomycosis than immune defense. © The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail journals.permissions@oup.com.BACKGROUND Although computed tomography (CT) is considered the gold standard for investigating skeletal muscles, diagnostic cut-off points for sarcopenia have not been established. We therefore suggested clinically relevant diagnostic cut-off points for sarcopenia based on reference values of skeletal muscle area (SMA) measured by CT scan in a large-sized healthy Asian population. METHODS This cross-sectional analysis included 11,845 subjects (7,314 men, 4,531 women) who underwent abdominal CT scans in South Korea. SMA including all muscles on the selected axial images of the L3 lumbar vertebrae level was demarcated using predetermined thresholds (-29 to +150 Hounsfield units). SMA indices (height-, weight-, BMI-adjusted) were calculated. RESULTS When T-score less then -2.0 was used as the cut-off for defining sarcopenia, the sex-specific cut-off points of SMA, SMA/height2, SMA/weight, and SMA/BMI were 119.3 cm2 and 74.2 cm2, 39.8 cm2/m2 and 28.4 cm2/m2, 1.65 cm2/kg and 1.38 cm2/kg,

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