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https://www.selleckchem.com/products/tetrathiomolybdate.html 80 ± 1.01 μM, 32.32 ± 1.01 μM, and 75.20 ± 1.02 μM, respectively. Further pharmacological characterization revealed a mixed-mode inhibition for 5, a competitive inhibition for 7, while 11 acted as a non-competitive inhibitor. Chemical and biocatalytic synthesis of seven previously undescribed marchantin A ester derivatives has been presented. Chemical synthesis afforded three peresterified bisbibenzyl products (TE1-TE3), while enzymatic method, using lipase, produced regioselective monoester derivatives (ME1-ME4). The antiproliferative activities of all prepared derivatives of marchantin A were tested on MRC-5 healthy human lung fibroblast, A549 human lung cancer, and MDA-MB-231 human breast cancer cell lines. All tested esters were less cytotoxic in comparison to marchantin A, but they also exhibited lower cytotoxicity against healthy cells. Monoesters displayed higher cytotoxic activities than the corresponding peresterified products, presumably due to the presence of free catechol group. Monohexanoyl ester ME3 displayed the same IC50 like marchantin A against MDA-MB-231 cells, but the selectivity was higher. In this way, regioselective enzymatic monoesterification enhanced selectivity of marchantin A. ME3 was also the most active among all derivatives against lung cancer cells A549 with the slightly lower activity and selectivity in comparison to marchantin A. Salpratins A-D (1-4), four new 4,5-seco-abietane diterpenoids, along with twelve known analogues, featuring diverse 6/6/6, 6/6/7, and 6/6/8 rings system, were isolated from Salvia prattii Hemsl. Particularly, salpratin A is the first example of 4,5;12,13-bis-seco-abietane diterpenoid features with a 5/6/6/6 ring system. Their structures were determined by analyses of comprehensive NMR and MS spectroscopic data and single-crystal X-ray diffractions. In addition, compounds 1, 3, 4, 6, 7, 8 and 14 showed potent vasorelaxant activity on endothelium-in

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