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https://www.selleckchem.com/ The present study evaluated outcomes after preplanned partial surgical removal of a large vestibular schwannoma (VS) followed by low-dose Gamma Knife surgery (GKS). Between January 2000 and May 2015, 47 patients with a unilateral VS (median maximum diameter 32mm) underwent preplanned partial tumor removal at our clinic. GKS for a residual lesion was done within a median time interval of 3months. The median prescription dose was 12 Gy. The median length of subsequent follow-up was 74months. The actuarial tumor growth control rates without a need for additional management at 3, 5, and 15years after GKS were 92%, 86%, and 86%, respectively. At the time of the last follow-up, the function of the ipsilateral facial nerve corresponded to House-Brackmann gradeI in 92% of patients. Significant improvement of ipsilateral hearing was noted in two patients after partial tumor removal and in one after GKS. Among 16 patients who presented with ipsilateral serviceable hearing, it was preserved immediately after surgery in 81% of cases and at the time of the last follow-up in 44%. Salvage surgical treatment was required in 9% of patients. Preplanned partial surgical removal followed by low-dose GKS provides a high level of functional preservation in patients with a large VS. Preplanned partial surgical removal followed by low-dose GKS provides a high level of functional preservation in patients with a large VS. To evaluate the results of combined management of large vestibular schwannomas (VS) with initial subtotal resection (STR) followed by adjuvant stereotactic radiosurgery (SRS), with a particular emphasis on the timing and regimen of irradiation. Seventeen patients underwent STR of a VS followed by SRS, whereas five others were observed after STR. Early SRS (<6months after surgery) and late SRS (>6months after surgery) were done in 8 and 9 patients, respectively. Single- and multisession SRS treatments were administered in 10 and 7 patients, respe

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