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Limitations of this study are discussed. While research has shown prescription drug misuse is an issue among Blacks overall, our results show that the role of ethnicity must not be overlooked, especially when tailoring prevention and intervention programs. Limitations of this study are discussed.The problem of plastic prevalence and associated pollution has grasped the entire planet drastically, putting all fields of science on the stake seeking remedies to this global havoc. To address this crisis, with a single remediation strategy is often found to be baseless, thereby much interest has been evoked in the development of multidisciplinary approaches - involving physico-chemical and biological strategies to nullify the aftermath of plastic pollution in all possible means. Even amidst, the availability of different approaches, the use of biological methods to combat plastic degradation has gained momentum. The most frequently used plastics appear in wide forms such as polyethylene plastic bags, polypropylene-based bottles, polyvinyl chloride pipes and polystyrene styrene cups. Plastic nicknamed as one of the toughest polymers viz. polycarbonate, acrylonitrile butadiene styrene (ABS) and Polydicyclopentadiene; quite often are called so as they resist degradation in normal environmental strategies. They are often degraded in non-hostile and harsh environments of pH, temperature, radiation etc. However, not always it is possible to create such harsh environments for plastic degradation. In such a scenario, the use of gut microbes that can withstand the harsh atmosphere of gut environment could serve as promising candidates for plastic biodegradation. The current article envisages the various gut microbes of various biological agents and their role in plastic remediation. The current review compiles the techniques available for plastic remediation, the microbial prospects of plastic remediation, its challenges, and possible breakthroughs to effective plastic remediation. Substance Use Disorder (SUD) continues to represent a significant public health crisis in the United States. Novel and effective treatments are needed, and third wave behavioral approaches focused on increasing mindfulness and psychological flexibility appear promising. However, the unique and shared impact of mindfulness and psychological flexibility on substance craving is not well understood. The current study explores how mindfulness and psychological flexibility predict substance craving while controlling for severity of substance dependence in a sample ( = 284) of treatment-seeking adults with SUD. Results suggest that mindfulness and psychological flexibility each account for unique variance in substance craving over and above the other. Implications and limitations are discussed. Substance Use Disorder (SUD) continues to represent a significant public health crisis in the United States. https://www.selleckchem.com/products/lificiguat-yc-1.html Purpose Novel and effective treatments are needed, and third wave behavioral approaches focused on increasing mindfulness and psychological flexibility appear promising. However, the unique and shared impact of mindfulness and psychological flexibility on substance craving is not well understood. Methods The current study explores how mindfulness and psychological flexibility predict substance craving while controlling for severity of substance dependence in a sample (N = 284) of treatment-seeking adults with SUD. Results and Discussion Results suggest that mindfulness and psychological flexibility each account for unique variance in substance craving over and above the other. Implications and limitations are discussed. Nonmedical use of prescription stimulants (NMPS) has increased on college campuses during the past two decades. NMPS is primarily driven by academic enhancement motives, and normative misperceptions exist as well. However, large, nationwide studies have not yet been conducted to generalize findings more broadly and gain a deeper understanding of the relationship between NMPS and other substance use (e.g. alcohol use, marijuana, etc.). The present study was conducted to lay the foundation for prevention efforts related to NMPS by establishing NMPS prevalence, practices surrounding NMPS, and other substance use. = 2,989 students from seven universities around the U.S. completed a web-based survey assessing NMPS practices and related behaviors. Prevalence and factors associated with NMPS were explored. Analyses revealed a 17% past-year prevalence of NMPS with associated widespread misperceptions of peer use. NMPS was significantly related to alcohol use, binge drinking, and marijuana use, as well as skipped classes and affiliation with Greek life. Although most college students do not report NMPS, those who do also are more likely to report alcohol use, binge drinking, and marijuana use, and NMPS could be a "red flag" for other risk behaviors worth exploring. Implications for prevention and intervention are discussed. Although most college students do not report NMPS, those who do also are more likely to report alcohol use, binge drinking, and marijuana use, and NMPS could be a "red flag" for other risk behaviors worth exploring. Implications for prevention and intervention are discussed.Cytochrome P4501B1 is a ubiquitous family protein that is majorly overexpressed in tumors and is responsible for biotransformation-based inactivation of anti-cancer drugs. This inactivation marks the cause of resistance to chemotherapeutics. In the present study, integrated in-silico approaches were utilized to identify selective CYP1B1 inhibitors. To achieve this objective, we initially developed different machine learning models corresponding to two isoforms of the CYP1 family i.e. CYP1A1 and CYP1B1. Subsequently, small molecule databases including ChemBridge, Maybridge, and natural compound library were screened from the selected models of CYP1B1 and CYP1A1. The obtained CYP1B1 inhibitors were further subjected to molecular docking and ADMET analysis. The selectivity of the obtained hits for CYP1B1 over the other isoforms was also judged with molecular docking analysis. Finally, two hits were found to be the most stable which retained key interactions within the active site of CYP1B1 after the molecular dynamics simulations.
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