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https://www.selleckchem.com/Androgen-Receptor.html Given the high mortality, early diagnosis and appropriate therapy can provide patients with a favorable prognosis.BACKGROUND sRAGE (soluble receptor for advanced glycation end products) is identified as playing a protective role in chronic inflammatory diseases, and it has been found to be related to arterial stiffness in hypertensive or diabetic patients. This cross-sectional study was designed to study the potential association of sRAGE with arterial stiffness in systemic lupus erythematosus(SLE) patients. METHODS Ninety-four female SLE patients were enrolled. Brachial-ankle pulse wave velocity (baPWV) was measured by an automatic pulse wave analyzer. Those patients were divided into two groups according to baPWV values, those with values greater than 1400cm/s being defined as the high arterial stiffness group. Biochemical parameters were compared between the two groups. Linear and logistic regression analysis was used to observe the association between sRAGE and arterial stiffness in those patients. RESULTS Thirty-five patients were defined as being in the high arterial stiffness group in which sRAGE levels were lower (P less then 0.05). sRAGE levels were significantly related to baPWV(standardized β=1.18, P less then 0.01) by linear regression analysis. Multivariate logistic regression analysis showed that sRAGE, SLE duration, systolic blood pressure and low-density lipoprotein cholesterol were independent predictors of arterial stiffness in those patients. CONCLUSION Our results revealed that sRAGE was negatively associated with arterial stiffness in Chinese female SLE patients. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.BACKGROUND Hypoxia (deprived oxygen in tissues) may induce molecular and genetic changes in cancer cells. OBJECTIVE Investigating the genetic changes of glucose metabolism in breast cancer cell line (MCF7) after exposure to continuous hypoxia

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