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https://www.selleckchem.com/products/azeliragon.html Cytokines are a family of proteins which play a major role in the regulation of the immune system and the development of several diseases, from rheumatoid arthritis to cancer and, more recently, COVID-19. Therefore, many efforts are currently being developed to improve therapy and diagnosis, as well as to produce inhibitory drugs and biosensors for a rapid, minimally invasive, and effective detection. In this regard, even more efficient cytokine receptors are under investigation. In this paper we analyze a set of IL-6 cytokine receptors, investigating their topological features by means of a theoretical approach. Our results suggest a topological indicator that may help in the identification of those receptors having the highest complementarity with the protein, a feature expected to ensure a stable binding. Furthermore, we propose and discuss the use of these receptors in an idealized experimental setup.Under strong winds and at low temperatures, heat loss of hot-mix asphalt mixtures is likely to occur, which leads to temperature segregation. Temperature segregation affects the forming quality and the performance of asphalt pavements. In this study, a phase-change thermal-insulation agent (PCTIA) was prepared for reducing the temperature dissipation. A cooling simulation experiment was performed to test the temperature-dissipation process for an ordinary asphalt mixture and the asphalt mixture mixed with PCTIA (AM-PCTIA). The thermal-insulation effect was analyzed according to the temperature difference and the thermal-insulation extension time. Moreover, two indices-the thermal-insulation accumulated time difference value (IATDV) and thermal-insulation accumulated time difference index (IATDI)-were proposed for evaluating the thermal-insulation ability and efficiency. The results indicated that the temperature at the center of the AM-PATIA was 4 °C higher than that for the ordinary asphalt mixture. The insulatio

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