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https://www.selleckchem.com/products/Sunitinib-Malate-(Sutent).html on in dose to multiple organs at risk vs the manual plan with a maximum value which ranged between 10.8 and 12.9 Gy for the three patients. The trade-off of the OAR dose reduction resulted in higher dose to no more than one OAR for each of the selected MCBOO plans vs the manual plan. The maximum dose increase in the MCBOO plans over the manual plan ranged from 7.8 to 11.8 Gy. CONCLUSIONS A novel multicriteria beam orientation optimization method was developed and tested on three IMPT patient cases. The method automatically generates Pareto plans database by exploring the noncoplanar beam orientations. The method was able to identify beam orientations with Pareto optimal plans that are comparable to the manually created plans with varying objective trade-offs. © 2020 American Association of Physicists in Medicine.OBJECTIVE Future time perspective (FTP) refers to individuals' perceptions of the future as either open-ended or limited. Despite well-documented individual differences in FTP across the adult life span, little is known about short-term variations of FTP within individuals and the within-person associations between FTP and affective experiences. METHOD Study 1 used data from a daily diary study over 10 days (N = 564) with a wide age range across the adult life span (M = 48.30). Study 2 used data from an ambulatory assessment study over 10 days (N = 136) obtained from healthy older adults (M = 70.45). RESULTS Findings suggest that 10% to 20% of the total variance in FTP was within-person and 29% to 62% of the total variance in affect was within-person. Multilevel modeling showed that occasions with a more open-ended FTP were occasions with more positive affect, energetic arousal, calmness, and positive valence, and less negative affect. Age moderated the within-person associations between FTP and positive and negative affect as well as energetic arousal, with weaker associations for older adu

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