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https://www.selleckchem.com/products/nvl-655.html High levels of obesity, weight gain, lower FEV1/FVC values and the need for nocturnal supplementary oxygen independently predicted CPAP failure. CPAP therapy for severe OHS in patients who have these risk factors should be closely monitored in the long-term for possible treatment failure. CPAP therapy for severe OHS in patients who have these risk factors should be closely monitored in the long-term for possible treatment failure. Previous studies show inconsistent results on the role of innervation imaging (with I-123-mIBG) and perfusion imaging in predicting appropriate ICD therapy (aICDth). These studies included patients with both dilated and ischemic cardiomyopathy. This study compared the ability of I-mIBG imaging along with perfusion imaging (using thallium-199) to predict aICDth in patients with ischemic heart failure (IHF) in relation to indication for ICD implantation (primary vs. secondary prevention of sudden cardiac death (SCD)). mIBG/thallium SPECT imaging were performed before ICD implantation in 80 patients with IHF 49 candidates for primary and 31 for secondary SCD prevention. During a mean follow-up of 18months, the imaging results could not predict patients with appropriate ICD therapy among patients with ICD implants for primary SCD prevention. While in the secondary SCD prevention group, those who received a ICDth had significantly larger summed scores of regional perfusion and innervation impairment, but not higher heart-to-mediastinal mIBG ratio. The best results to predict aICDth were using mIBG summed score (cut-off point > 34%, sensitivity 72%, specificity 100%, AUC 0.909, P < 0.0001). The prognostic value of innervation and perfusion imaging in patients with IHF differ based on indication for ICD implantation (primary vs. secondary prevention of SCD). The prognostic value of innervation and perfusion imaging in patients with IHF differ based on indication for ICD implantation (primary vs. s

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