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https://www.selleckchem.com/products/zk53.html S TRO19622 improves mitochondrial dysfunction but enhances Aβ levels in disease models of AD. Further studies must evaluate whether TRO19622 offers benefits at the mitochondrial level despite the increased formation of Aβ, which could be harmful. BACKGROUND Cognitive impairment and frailty are highly prevalent in older adults undergoing transcatheter aortic valve replacement. This study aimed to investigate the relationship of cognitive impairment and frailty with functional recovery after transcatheter aortic valve replacement. METHODS This was a single-center prospective cohort study of 142 patients who were ≥70 years old and underwent transcatheter aortic valve replacement for aortic stenosis. Before transcatheter aortic valve replacement, cognitive impairment was defined as Mini-Mental State Examination score less then 24 points (range 0-30) and moderate-to-severe frailty was defined as a deficit-accumulation frailty index ≥0.35 (range 0-1). The functional status composite score, the number of 22 daily and physical tasks that a patient could perform independently, measured at baseline and 1, 3, 6, 9, and 12 months postoperatively were analyzed using linear mixed-effects model. RESULTS The mean age was 84.2 years, with 74 women (51.8%). Patients with moderate-to-severe frailty and cognitive impairment (n=27, 19.0%) had the lowest functional status at baseline and throughout 12 months, while patients with mild or no frailty and no cognitive impairment (n=48, 33.8%) had the best functional status. Patients with cognitive impairment alone (n=19, 13.4%) had better functional status at baseline than those with moderate-to-severe frailty alone (n=48, 33.8%), but their functional status scores merged and remained similar during the follow-up. CONCLUSIONS Preoperative cognitive function plays a vital role in functional recovery after transcatheter aortic valve replacement, regardless of baseline frailty status. Impaired cogn

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