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https://www.selleckchem.com/products/Nutlin-3.html We develop a label-free fluorescence method for ultrasensitive detection of apoptosis-associated caspase activity based on branched rolling circle amplification. This work demonstrates for the first time the use of a nucleic acid amplification strategy for the amplified detection of caspase activity, which allows for highly sensitive detection of endogenous caspase even at the single-cell level. This method can be further applied for kinetic analysis and inhibitor screening.In this work, an Eu2+-doped K3ScSi2O7 (KSSO) NIR phosphor with broad-band NIR emission and robust thermal stability was designed and synthesized successfully. The crystal structure, luminescent properties, the mechanism of abnormal NIR emission, thermal stability and application to NIR pc-LEDs were investigated in detail.Pnictogen complexes are ideal for mediating multi-electron chemical reactions in two-electron steps. We report an Sb(v) bis-μ-oxo corrole that photochemically oxidises the C-H bonds of organic substrates. In the case of toluene, the substrate is oxidised to benzaldehyde, a rare example of a four-electron photoreaction.Theranostic agents that integrate diagnostic and therapeutic modalities have drawn extensive attention due to their ability to deliver real-time imaging-guided tumor treatment. Herein, a novel core-shell polydopamine (PDA)-based theranostic agent (PDA@TA-Fe) was fabricated via a two-step strategy. Upon 808 nm and 1064 nm laser irradiation, this agent exhibited high photothermal conversion efficiencies of 29% and 41%, respectively. After endocytosis into tumor cells, the TA-Fe shell of PDA@TA-Fe gradually disintegrated in the weakly acidic tumor microenvironment (TME), and released the TA as an acidity-activated reductant that could reduce Fe3+ to Fe2+. Subsequently, the generated Fe2+ reacted with H2O2 to generate toxic hydroxyl radicals (˙OH) via the Fenton reaction, which induced the apoptosis of tumor cells and a

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