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https://www.selleckchem.com/products/polyethylenimine.html Our results suggest that Wxmw is a promising allele to improve grain quality, especially ECQ and grain transparency of high-yielding japonica cultivars, in rice breeding programs.An organocatalytic atroposelective strategy for accessing enantioenriched axially chiral IAN analogues was developed for the first time. A class of novel atropisomeric C2-arylquinoline skeletons were synthesized with high enantiocontrol via chiral phosphoric-acid-catalyzed heteroannulation of in situ generated vinylidene ortho-quinone methide (VQM) intermediates with ortho-aminophenones. The strategy tolerated a broad substrate scope, providing a facile organocatalytic approach to IAN analogues in good yields and excellent enantioselectivities under mild reaction conditions. Moreover, the synthetic utility of this methodology was illustrated through further transformations into IAN-type ligand and axially chiral thiourea. Secular trends of dementia prevalence and incidence have rarely been studied in the Chinese population. We examined the changes in dementia prevalence and incidence by comparing data from Shanghai Epidemiological Survey of Dementia and Alzheimer's disease (SESD) and Shanghai Aging Study (SAS) conducted two decades apart. The dementia prevalence and incidence in total participants in SAS were higher than that in SESD (prevalence 6.44% vs 2.30%, P<.001; annual incidence 2.58% vs 1.33%, P<.001). In participants with ≤6 years of education, the dementia prevalence in SAS was higher than that in SESD (6.39% vs 3.07%, P<.001); the annual dementia incidence in SAS was double that in SESD (3.63% vs 1.80%, P=.019). We observed an increasing trend of dementia prevalence and incidence in the Chinese elderly, especially those with low education. The dramatic rise in numbers of people with dementia may happen most likely in low-educated populations. We observed an increasing trend of dementia prevalence and incidence in the Chin

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