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https://www.selleckchem.com/products/jq1.html of hosts are rather poorly characterized. Here, we present the transcriptional organization of the stability module and show that gene transcript dosage effect is an important determinant of the RA3 stable maintenance in different hosts.Streptomyces is well-known for biosynthesis of secondary metabolites with diverse bioactivities. Although oils have been employed as carbon sources to produce polyketide antibiotics for several industrial Streptomyces strains, the intrinsic correlation between oil utilization and high production of antibiotics still remains unclear. In this study, we investigate the correlation between oil metabolism and salinomycin biosynthesis in Streptomyces albus ZD11 which employs soybean oil as the main carbon source. Comparative genomic analysis revealed the enrichment of genes related to triacylglycerol (TAG) metabolism in S. albus ZD11. Transcriptomic profiling further confirmed the enhancement of TAG metabolism and acyl-coenzyme A biosynthesis in S. albus ZD11. Multiple secreted lipases, which catalyze the TAG hydrolysis, were seen to be working in a synergistic and complementary manner in aiding the efficient and stable hydrolyzation of TAGs. Together, our study suggests that enhanced TAG hydrolysis and fatty acid degradation contribute to the high-efficientcy of oil utilization in S. albus ZD11 in order to provide abundant carbon precursors for cell growth and salinomycin biosynthesis.Importance In order to obtain a high production of antibiotics, oils have been used as the main carbon source for some Streptomyces strains. Based on multi-omics analysis, this study provides insight into the relationship between triacylglycerol (TAG) metabolism and antibiotic biosynthesis in S. albus ZD11, an oil-preferring industrial Streptomyces strain. Our investigation into TAG hydrolysis gave the further evidence that this strain utilized complicated strategies enabling an efficient TAG metabolism. In addit

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