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https://www.selleckchem.com/products/agk2.html 05 or P less then 0.01). Both drugs increased the serum levels of Ach and decreased the serum levels of Aβ42 and Tau (all P less then 0.05). There was no significant difference in these variables between the two groups, which showed that JYF was not inferior to donepezil. No obviously significant changes were observed in the ADL. No severe adverse events were observed in both groups. CONCLUSION The effect and safety of JYF for the treatment of AD were not inferior to those of donepezil.OBJECTIVE To investigate protective effects of hirudin on oxidative stress and apoptosis of spinal dorsal root ganglion cells in high-glucose rats at the cellular and molecular level. METHODS Dorsal root ganglion neurons (DRGn) were harvested from embryonic day in 15 SD rats, purified and identificated after primary culture. They were divided into the normal control group, high-glucose (HG) group, positive control (alpha-lipoic acid, ALA) group, low-dose hirudin group (H1), medium-dose hirudin group (H2) and high-dose hirudin group (H3). The control group was cultured by neuron specific culture medium, while the HG group was cultured by neuron specific culture medium and 20 mmol/L glucose (HG medium). The hirudin groups were cultured by HG medium+0.25 IU/mL hirudin (H1), HG medium+0.5 IU/mL hirudin (H2) and HG medium+1 IU/mL hirudin (H3). The ALA group was cultured by HG medium+100 µ mol/L ALA. 3-(4,5-dimethylthiazol-2-yl)-2, 5-diphenylt etrazolium bromide (MTT) assay was used to explore the optimum concentra0.05). The expression of NF-κ B (P65) protein in H3 group were lower than those of HG group (P less then 0.05). The expression of Nrf-2 protein in hirudin groups was higher than that of HG group (P less then 0.01), lower than that of ALA group (P less then 0.01 or P less then 0.05). The expression of HO-1 protein in hirudin groups was lower than that of ALA group (P less then 0.01 or P less then 0.05), higher than that of HG group (P

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