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https://www.selleckchem.com/products/DMXAA(ASA404).html Voxel based modeling is a very attractive way to represent complex multi-material objects. Beside artistic choices of pixel/voxel arts, representing objects as voxels allows efficient and dynamic interactions with the scene. For geometry processing purposes, many applications in material sciences, medical imaging or numerical simulation rely on a regular partitioning of the space with labeled voxels. In this article, we consider a variational approach to reconstruct interfaces in multi-labeled digital images. This approach efficiently produces piecewise smooth quadrangulated surfaces with some theoretical stability guarantee. Non-manifold parts at intersecting interfaces are handled naturally by our model. We illustrate the strength of our tool for digital surface regularization, as well as voxel art regularization by transferring colorimetric information to regularized quads and computing isotropic geodesic on digital surfaces.A 34 mm aperture transducer was designed and tested for proof of concept to ablate tissue using an endocavity histotripsy device. Several materials and two drivers were modelled and tested to determine an effective piezoelectric-matching layer combination and driver design. The resulting transducer was fabricated using 1.5 MHz porous PZT and PerFORM 3D printed acoustic lenses and was driven with a multi-cycle class-D amplifier. The lower frequency, compared to previously developed small form-factor histotripsy transducers, was selected to allow for more efficient volume ablation of tissue. The transducer was characterized and tested by measuring pressure field maps in the axial and lateral planes, and pressure output as a function of driving voltage. The axial and lateral full-width-half-maximums of the focus were found to be 6.1 and 1.1 mm, respectively. The transducer was estimated to generate 34.5 MPa peak negative focal pressure with a peak to peak driving voltage of 1345 V. Performa

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