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https://www.selleckchem.com/products/ABT-263.html Multivariate analysis showed strong association of these features with the risk of surgery but failed to reach statistical significance. US features may potentially be used as point-of-care tools to aid clinicians in the assessment of the surgical risk in patients with Stricturing Crohn's Disease. US features may potentially be used as point-of-care tools to aid clinicians in the assessment of the surgical risk in patients with Stricturing Crohn's Disease. Opioid use is a topic of growing concern among patients with non-alcoholic fatty liver disease (NAFLD). Given safety concerns of opioids, proactively identifying subgroups of patients with an increased probability of opioid use may encourage practitioners to recommend alternative therapies for pain, thus reducing the likelihood of opioid misuse. This work assessed the prevalence and patient characteristics associated with opioid use in a real-world cohort of patients with NAFLD. TARGET-NASH, an observational study of participants at 55 academic and community sites in the United States, includes patients with NAFLD defined by pragmatic case definitions. Opioid use was defined as any documented opioid prescriptions in the year prior to enrollment. The association between patient characteristics and the odds of opioid use were modeled with stepwise multivariable logistic regression and tree ensemble methods (CART/Boosted Tree). The cohort included 3,474 adult patients with NAFLD including 18.2% with documented opioid use. Variables associated with opioid use included presence of cirrhosis (OR 1.47, 95% CI 1.12-1.92), BMI ≥32 kg/m2 (OR 1.31, 95% CI 1.06-1.61), depression (OR 1.87, 95% CI 1.50-2.33) and anxiety (OR 1.61, 95% CI 1.30-2.01). In the boosted tree analysis, history of back pain, abdominal pain, BMI and depression had the greatest relative importance in predicting opioid use. Prescription opioids were used in nearly one of five patients with NAFLD. Given the

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