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https://www.selleckchem.com/products/at13387.html Parasellar spaces remain particularly singular, comprising most important neurovascular structures as internal carotid artery, optic, oculomotor and trigeminal nerves. Meningiomas are one of the most frequent tumors arising from parasellar spaces. In this location, meningiomas remain mostly benign tumors with WHO grade I and meningothelial subtype. Progestin intake should be investigated and leads mostly to conservative strategy. In case of benign non-symptomatic tumor, observation should be proposed. Tumor growth will lead to propose surgery or radiosurgery. In case of uncertain diagnosis and aggressive pattern, a precise diagnosis is required. For cavernous sinus and Meckel's cave lesions, complete removal is rarely considered leading to propose endoscopic endonasal or transcranial biopsy. Optic nerve decompression could also be proposed via these both approaches. A case by case discussion about the best approach is recommended. Transcranial approach remains necessary for tumor removal in most cases. Vascular injury could lead to severe complications. CSF leak, meningitis, venous sacrifice, visual impairment and cranial nerves palsies are more frequent complications. Pituitary dysfunctions are rare in preoperative assessment as in postoperative follow-up but should be assessed in case of meningiomas located close to the pituitary axis. Long-term follow-up is required given the frequent incomplete tumor removal and the risk of delayed recurrence. Radiosurgery is relevant for small and well-limited meningiomas or intra-CS postoperative residue, whereas RT and proton beam therapy are indicated for large extended non-operable meningiomas. The place of the peptide receptor radionuclide therapy needs to be defined. Targeted therapy should be considered in rare recurrent and aggressive parasellar meningiomas.Primates are hypothesized to "fall back" on challenging-to-process foods when preferred foods are less available. S

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