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https://www.selleckchem.com/products/calcium-folinate.html The decreased traps of photo-induced electrons at surface defect states effectively facilitate the PICT efficiency within the substrate-molecule system. An ultrahigh enhancement factor of 7.7 × 105 and low limit of detection (1 × 10-7 M) for a 4-mercaptopyridine molecule at a temperature of 77 K are successfully obtained. More importantly, the low temperature-enhanced SERS effect is also obtainable in other metal oxide semiconductors, such as d-TiO2 and d-Cu2O nanoparticles. To the best of our knowledge, this is the first time the low temperature-boosted SERS activity of semiconductors has been observed. This study not only provides a deep insight into the chemical SERS mechanism, but also develops a novel strategy for improving semiconductor SERS sensitivity. The strong SERS activity at a low temperature reported here may open new avenues for developing non-metal SERS substrates with new functionalities, especially for the research on cryogenic sensing and hypothermal medicine.Detecting specific protein glycoforms is attracting particular attention due to its potential to improve the performance of current cancer biomarkers. Although natural receptors such as lectins and antibodies have served as powerful tools for the detection of protein-bound glycans, the development of effective receptors able to integrate in the recognition both the glycan and peptide moieties is still challenging. Here we report a method for selecting aptamers toward the glycosylation site of a protein. It allows identification of an aptamer that binds with nM affinity to prostate-specific antigen, discriminating it from proteins with a similar glycosylation pattern. We also computationally predict the structure of the selected aptamer and characterize its complex with the glycoprotein by docking and molecular dynamics calculations, further supporting the binary recognition event. This study opens a new route for the identification of

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