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https://www.selleckchem.com/products/cyclo-rgdyk.html Cadmium (Cd) is a heavy metal, which is widely used in the industry and daily life. It has a long half-life, so large amounts of Cd can accumulate in humans and become toxic. Chlorogenic acid (CGA) can eliminate free radicals and inhibit lipid peroxidation and is mainly used to prevent metal toxicity. In the present study, mice are given CGA by intraperitoneal injection or gavage, respectively, to explore the mechanism of preventing Cd toxicity. In acute Cd-exposed mice, CGA treatment (ip) alleviated Cd-induced oxidative damage and reduced the production of NO and MPO in the liver and kidney tissues, while TLR4 expression levels did not change significantly. After 8 weeks of Cd exposure, CGA administration (gavage) significantly alleviated gut dysbiosis by decreasing the Firmicutes to Bacteroidetes ratio, enhancing the relative abundances of bacteria, including Ruminiclostridium_9, Alloprevotella, and Rikenella, and inhibiting the activation of the TLR4/MyD88/NF-κB signaling pathway. These findings suggested that protection mechanisms underlying the oral administration of CGA against the Cd-induced hepatorenal injury was related to the regulation of the intestinal flora balance. CGA can be used as an effective component in daily diet to prevent Cd toxicity.Enhancement of fluorescence emission from single-photon quantum emitters on plasmonic nanomaterials using surface plasmon-coupled emission (SPCE) platforms has seen significant advancements. In parallel, there has also been an exponential rise in applications involving two-dimensional (2D) transition-metal dichalcogenides (TMDs) that exhibit unique exciton-plasmon interactions. Although both these Frontier research areas have impacted the development of sensor and sensing technologies, no study coalesces these two arenas for translational applications. In this work, we use thin WS2 nanosheets for realizing 1000-fold fluorescence enhancement on the SPCE platform

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