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https://www.selleckchem.com/products/luzindole.html An esophagectomy is the key component of curative esophageal cancer treatment. Textbook outcome is a composite measure describing an optimal perioperative course, including parameters regarding a radical resection with at least 15 lymph nodes and an uncomplicated postoperative course without hospital readmission. This study assessed clinicopathological predictors for textbook outcome and the association of textbook outcome with survival in two tertiary referral centers. All esophageal cancer patients who underwent an esophagectomy with gastric tube reconstruction and curative intent between 2007-2016 were included. Patients with a carcinoma in situ and patients undergoing a salvage or non-elective procedure were excluded. Primary endpoint was the association of textbook outcome for esophageal cancer surgery with long-term survival. Secondary endpoints were clinicopathological predictors for textbook outcome. In total, 1065 patients were included, of whom 327 achieved textbook outcome (30.7%). Squamous cell carcinoma (OR 0.56, 95%CI 0.39-0.80), hybrid approach (OR 0.30, 95%CI 0.10-0.89), and ASA class ≥2 predicted worse textbook outcome-rate (ASA-II OR 0.33, 95%CI 0.22-0.49; ASA-III/IV OR 0.68, 95%CI 0.48-0.96), whereas neo-adjuvant therapy predicted better textbook outcome-rate (OR 1.58, 95%CI 1.08-2.31). Superior overall (HR 0.77, 95%CI 0.64-0.93) and disease-free survival (0.80, 95%CI 0.67-0.96) were observed in the textbook outcome group. Achieved textbook outcome was associated with better overall and disease-free survival, illustrating the association of improved short-term outcomes and long-term survival and the importance of pursuing textbook outcome. Achieved textbook outcome was associated with better overall and disease-free survival, illustrating the association of improved short-term outcomes and long-term survival and the importance of pursuing textbook outcome. Intraoperative molecular imaging (IMI) m

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