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https://www.selleckchem.com/products/srpin340.html 001), changes from married and living together with spouse/registered partnership to another marital status (β=-.71, p less then .001), decreases in log income (β=-.01, p less then .05), worsening self-rated health (β = .04, p less then .001), functional decline (β = .09, p less then .001), increases in depressive symptoms (β = .13, p less then .001) and decreases in cognitive functioning (β=-.01, p less then .001), whereas it was not associated with changes in chronic diseases. CONCLUSION Our longitudinal study based on nationally representative SHARE data contributed to identify the determinants of loneliness among older Europeans using panel data methods. Tackling the identified risk factors may assist in avoiding loneliness in older adults living in Europe. OBJECTIVE Although stress is an important component of irritable bowel syndrome (IBS) pathophysiology, the possibility that work-related stress is implicated in the pathophysiology of IBS has not been widely studied. This study aimed to examine whether job strain (a combination of high job demands and low control at work) and/or burnout, the outcome of a gradual depletion of energetic resources resulting from chronic exposure to work-related stress, are associated with IBS. METHODS Fifty-five patients fulfilling the Rome III criteria for IBS and 214 matched healthy controls (HC) participated in this cross-sectional study. All participants completed a job strain measure, the Shirom - Melamed Burnout Measure (SMBM), and dietary and health questionnaires. RESULTS There was no significant difference in the prevalence of job strain between IBS patients and HC (25.5% vs. 23.0%, respectively). Job strain was not associated with increased IBS prevalence (adjusted OR = 1.99, 95% CI 0.54-7.33). In contrast, the mean burnout score in the IBS group was significantly higher than in HC (2.9 ± 1.1 vs. 2.1 ± 0.8, p less then .001). Burnout was associated with a 2.41-fold ele

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