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https://www.selleckchem.com/products/Temsirolimus.html BACKGROUND AND PURPOSE Radiation-induced brain injury (RBI) usually occurs six months to three years after irradiation, often shows cognitive dysfunction, epilepsy, and other neurological dysfunction. In severe cases, it can cause a wide range of cerebral edema, even herniation. It seriously threatens the survival of patients and their quality of life, and it becomes a key factor in limiting the radiation dose and lowering the therapeutic efficacy in recent years. Therefore, studying the pathogenesis of RBI and exploring new therapeutic targets are of great significance. METHODS In our study, we observed the activation and secretory function in astrocytes as well as the intracellular signal transducer and activator of transcription 3 (STAT3) signal transduction pathway activation status after exposing different doses of X-ray irradiation by using MTT, Immunocytologic analysis, and Western blot analysis. Further, we used the same way to explore the role of vascular endothelial growth factor (VEGF) in signal tr Authors. Brain and Behavior published by Wiley Periodicals, Inc.MCM-41-supported ZnO-Cu(OH)Cl nanoparticles were synthesized via an incipient wetness impregnation technique using zinc chloride and copper chloride salts as well as water at room temperature. The catalyst was characterized by powder X-ray diffraction (PXRD), infrared spectroscopy (IR), and TGA, whereas surface and morphological studies were performed by using scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The above studies revealed the incorporation of metal species into the pores of MCM-41, leading to a decrease in surface area of the nanoparticles that was found to be 239.079 m2 /g. The substituents attached to the ketone determine the rate of the reaction, and the utilization of the green solvent 'water' astonishingly completes the hydrogenation reaction in 45 minutes at 40 °C with 100% conversion and 100% se

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