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https://www.selleckchem.com/products/k03861.html The main initiator of the development of PAH is the development of endothelial dysfunction of the pulmonary vessels. The cause of this dysfunction is associated with functional disorders of the serotonin system. This research is devoted to study the role of the serotonin system in the development mechanism of PAH in children with CHD. We examined 30 young children (from 1 month to 2 years) with congenital heart defects (CHD), which were divided into 3 groups group I - 12 children with CHD complicated by pulmonary arterial hypertension (PAH); Group II - 9 children with CHD, not complicated by PAH; Group III - 9 relatively healthy children (control). The serotonin content of platelets, serum and serotonin transporter (SERT) in platelets was determined. To determine serotonin and its carrier, a quantitative enzyme-linked immunosorbent assay (Elisa kit) was used. The study was performed using the Serotonin ELISA diagnostic kit, IBL Hamburg at the automatic ELISA of the Evolis robotic station (BioRad). The resultspment of PAH in children with CHD.There are two main types of operative treatment for femoral shaft fractures in children with age 6 to 15 years old Osteosynthesis by Titanium Elastic intramedullary nails (TEN) and osteosynthesis by plate. In our study we analyzed 137 patients from 6 to 15 years of age with pediatric femoral shaft fractures and divided them into two groups according to methods of osteosynthesis 76 patients in "TEN group" and 61 in "Plate group". According to Flynn's scoring criteria for both groups there were excellent result for 106 patients (77%) from 137, satisfactory result for 23 patients (17%) and 8 patient with poor result (6%). There was not significant statistical difference between groups. There was significant difference between groups according to operation duration and hospital stay. These times were much shorter for the TEN group than for the Plate group. Time for starting partial we

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