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https://www.selleckchem.com/products/ly3295668.html We would like to underline that a personalised clinical approach remains of utmost importance in each patient treated by protocolised medicine. This is particularly true when acute MI occurs at a young age, since the underlying cause more frequently differs from the conventional atherosclerotic process in this patient category.Guidelines suggest using frailty characteristics in the work-up for a transcatheter aortic valve implantation (TAVI). There are many frailty-screening tools with different components. The prognostic value of the individual parameters in frailty is as yet unclear. The objective of this systematic review and meta-analysis was to find and pool predictors for 1‑year mortality after TAVI. We followed a two-step approach. First, we searched for randomised controlled trials on TAVI to identify frailty parameters used in these studies. Second, we searched for publications on these frailty parameters. Articles were included for pooled analysis if the studied frailty parameters were dichotomised with clear cut-off values based on common standards or clinical practice and reported adjusted hazard ratios (HR) of 1‑year mortality after TAVI. We calculated pooled effect estimates of 49 studies based on dichotomised frailty scores (HR 2.16, 95% CI 1.57-3.00), chronic lung disease (HR 1.57, 95% CI 1.45-1.70), estimated glomerular filtration rate less then 30 ml/min (HR 1.95, 95% CI 1.68-2.29), body mass index less then 20 kg/m2 (HR 1.49, 95% CI 1.09-2.03), hypoalbuminaemia (HR 1.77, 95% CI 1.38-2.25), anaemia (HR 2.08, 95% CI 0.93-4.66), low gait speed (HR 13.33, 95% CI 1.75-101.49) and Katz activities of daily living (ADL) score of 1 or more deficits (HR 5.16, 95% CI 0.77-34.47). Chronic lung disease, chronic kidney disease, underweight, hypoalbuminaemia, a low frailty score, anaemia, low gait speed and an ADL deficiency were associated with worse 1‑year outcomes after TAVI.PURPOSE Highlight and characteriz

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