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https://www.selleckchem.com/products/ono-7475.html Tumor necrosis factor- (TNF- ) is a proinflammatory factor involved in the pathogenesis of immunoglobulin A vasculitis (IgAV). The association between serum TNF- and disease severity in adult patients with IgAV nephritis (IgAV-N) has been inadequately evaluated. Serum TNF- was measured by chemiluminescence immunoassay in 53 renal biopsy-proved IgAV-N patients, 53 healthy controls, and 53 IgA nephropathy (IgAN) patients. The correlations of clinicopathologic parameters of IgAV-N patients with serum TNF- were analyzed. In this cross-sectional study, the median age of IgAV-N patients was 29 (25-37) years, and 67.9% were female. Serum TNF- was significantly higher in the IgAV-N group than in the healthy group [7.4 (5.7-9.4) pg/mL 5.9 (5.0, 7.1) pg/mL, = 0.001], but comparable with sex, age, and estimated glomerular filtration rate (eGFR) grade-matched IgAN patients. Serum creatinine ( = 0.006) and serum cystatin C ( = 0.001) were positively correlated with serum TNF- level, while albumin ( = 0.014) and eGFR ( = 0.021) were negatively correlated with serum TNF- level. Multivariate linear regression analysis revealed that eGFR ( = 0.007) was an independent clinical predictor of serum TNF- . Patients with higher pathological classification grade also had higher serum TNF- . Serum TNF- is associated with renal function and the pathological classification of adult patients with IgAV-N. TNF- is a potential biomarker for the assessment of IgAV-N severity. Serum TNF-α is associated with renal function and the pathological classification of adult patients with IgAV-N. TNF-α is a potential biomarker for the assessment of IgAV-N severity. The predictive value of soluble Klotho (sKlotho) for adverse outcomes in patients on maintenance hemodialysis (MHD) is controversial. In this study, we aimed to clarify the potential association of sKlotho levels with adverse outcomes in this patient population. A total of 211 patients on MHD wer

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