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https://www.selleckchem.com/products/ademetionine.html Fifteen patients were diagnosed with Inferior STEMI followed by 14 patients with Anterior and one with Lateral STEMI. The most common culprit artery was the left anterior descending coronary artery (14 patients). Six patients were in KİLLİP class II on admission and only one with Anterior STEMI was in severe pulmonary edema (KILLIP III) during intervention. All the procedures were successfully contemplated with 6 French Judkins catheters. Brachial spasm occurred in one patient which resolved with intra-arterial nitrate. Transfemoral approach was changed to LDR access in 4 patients due to severe bilateral iliac artery disease. Mean puncture time was 37.36 seconds. There were no radial occlusion, hematoma, hand neurologic deficit or bleeding. Patients were discharged in a mean time of 4.2 days. Conclusion Left distal radial artery can be used as an alternative safe and feasible access site for successful primary coronary interventions provided that it is performed by experienced operators.Background To study the effect of protein kinase TBK1 and IKKε inhibitor Amlexanox on cardiac function after acute myocardial infarction (AMI) in rats. Methods AMI model was established in rats. Experimental grouping sham + dimethyl sulfoxide (DMSO) group, sham + Amlexanox group, AMI + DMSO group, AMI + Amlexanox group. 12 h after surgery, rats in the sham + Amlexanox group and AMI + Amlexanox group were given an intraperitoneal injection of Amlexanox at a dose of 25 mg / kg once a day for 7 consecutive days. The sham + DMSO group and the AMI + DMSO group were given the same amount of DMSO as a control. Ultrasound was used to detect changes in cardiac function in rats for 3 and 7 days after continuous administration, and RT-PCR was used to detect the transcription levels of ISGs and apoptosis in myocardial tissue. HE and immunohistochemical staining were used to observe the inflammatory cell infiltration level and MOMA2 expressio

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